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do Carmo et al.

 
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PostPosted: Thu 4:38, 20 Jun 2013    Post subject: do Carmo et al.

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Asp is a microtubuleassociated protein that appears to mediate the interaction of centrosomes with spindle microtubules. Biochemical analyses show that Polo interacts with and phosphorylates Asp in vitro,[link widoczny dla zalogowanych], resulting in an MPM2 epitope (do Carmo et al., 2001). Furthermore,[link widoczny dla zalogowanych], extracts of polo1deprived embryos are incapable of supporting microtubule aster nucleation by saltstripped centrosomes; however,[link widoczny dla zalogowanych], addition of phosphorylated Asp or kinaseactive Polo protein can complement this defect (do Carmo et al., 2001),[link widoczny dla zalogowanych], indicating a common role of Polo and Asp in promoting the mitotic organizing activity of centrosomes.
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