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First Trimester PregnancyBecause of the high potential of birth defects and other adverse events, the first trimester of pregnancy is generally a contraindication to chemotherapy drugs, according to S. Mogotlane and colleagues in the 2005 "Juta's Manual of Nursing." However, some types of chemotherapy drugs are safe to administer during the second and third trimester of pregnancy. If the patient does not want to terminate the pregnancy, the doctor will generally wait until the second trimester to begin chemotherapy..
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